Brewpubs/Breweries

Church Brew Works - And on the seventh day, God had a cold one. This former church turned brewpub is a must see.
East End Brewing - Good things come in small packages. East End may be a small operation, but the beer is excellent, and you can't get it any fresher than going down for one of their "growler hours". Try the Big Hop, especially if you can find it on cask.
North Country - Just a short drive north of Pittsburgh in Slippery Rock is North Country brewpub.
Penn Brewery - If you enjoy German beers and food, this is the place to be. Their annual Oktoberfest celebration is always a fun affair, complete with authentic music and dress.
Rivertowne - They have locations in the east suburbs and north shore. including a brewpub and a pour house with a large selection of commerical beers. I have yet to make it to any, but the beer selection and prices are supposedly outstanding.
Rock Bottom - Brewpub chain located in Homestead. Their flagship beers are fairly ordinary, but they usually have something special on tap that is worth a try. AHA members get a discount.
Vodoo Brewing - Founded by Matt Allyn formerly of Four Sons Brewery, this brewery focuses on speciality beers such as their Belgain golden strong with cherries. You'll have to hit the bottle shops to get this brew, as I haven't seen it in any local pubs.
Full Pint Brewing - Brewery east of Pittsburgh in North Versailles, serving up an amber, IPA, witbier, and seasonals.

Hofbrauhaus Pittsburgh - Modeled after the real thing in Munich germany, including an outdoor beer garden. Located in the South Side Works, and serving authentic german lagers and weizens.

Laurel Highlands Meadery - Nano winery east of Pittsburgh focussed solely on meads. Owned by award winning meadmaker Matt Falenski.

Beaver Brewing Company - Nano brewery northwest of Pittsburgh known for unique beers, such as a Basil Amber and an India Porter Ale.

Helltown Brewing - Nano brewery in Mt. Pleasant, PA.

Beer Bars/Bottle Shops

1 For the Road - Previously, 3 Sons Dogs and Suds. Over 600 beers to choose from. Mix and match 6 packs. Thursdays are free tastings from 6-8 pm. Located in the North Hills. New owners have expanded hours and added taps.
Barley's and Hop's - Beer cafe and bottleshop in Bethel Park. Features 13 taps and a menu including wraps, salads, and appetizers.
Bites and Brews - Beer bar in Shadyside on Ellsworth. Huge selection of beer on draft, plus plenty of bottles. Food is standard bar fare, such as pizza and burgers.
Bocktown - Bar, Grille, and bottle shop in Robinson, with 2nd location opening in Beaver. Wed nights they have free tastings. The reuben is recommended.
Brews Brothers - 6-pack shop in Mt. Lebo.
D's SixPax and Dogz - A bottle shop and pub with a nice draft selection located in Regents Square. The bottle shop has a large selection of imports and craft beers.
FatHeads - No, it's not a life size sticker of Ben Roethlisberger. It's the best beer bar in the Burgh. Forty taps of craft and import brews, not to mention a bottle shop upstairs, and sandwiches big enough to feed a village. In the heart of the South Side.
Harris Grill - Bar and grill on Ellsworth Ave in Shadyside. Great outdoor spot, famous for Bacon night. Nice beer selection, but don't be suprised if the beer list is out of date.
Kazansky's Deli - Does a corned beef on rye and a cold Dogfish Head draft sound good? This isn't your everyday deli, with 10 taps and a huge bottle selection. Located on Murray Ave in Squirrel Hill.
Mad Mex - Numerous locations through Pittsburgh. Great selection of draft and bottled beers, and you can' beat the Happy Hour prices.
Piper's Pub - Beer Engines. If you've never had a hand pulled beer, you are missing out. Piper's has 3 beer engines serving ales from firkins. Match it up with some European football, aka soccer, and you may feel like you've transported across the Atlantic. In the South Side.
Pittsburgh Bottleshop Cafe - Restaurant and bar in Bridgeville.
Point Brugge Cafe - European Bistro serving traditional Belgian dishes like steamed mussels, frites, and carbonnade flamande. Check out their monthly beer dinners.
Sharp Edge - If you like Belgians, welcome to heaven. Easily the best Belgian draft selection in the Tri-State Area. The have 4 locations in Pittsburgh. Happy Hour means half price drafts!
Sidelines - This hole-in-the-wall in Millvale sports a lineup of 160 import and craft beers. The prices are so cheap, you might feel like you are committing highway robbery.
Beer Nutz Bottleshop and Grille - Restaurant and bottleshop in the Aspinwall/Blawnox area. Portions are not an issue here.
OTB Bicycle Cafe - Bar with nice tap selection right new South Side Works. Friendly to vegetarians.
Blue Dust - Craftbeer bar in the Homestead Waterfront area.
House of 1000 Beers - Located east of Pittsburgh in New Kensington, specializing in hard to find beers. 40 taps. I have heard great things about the selection, but a few complaints on freshness.

Homebrewing/Beer Clubs

American Homebrewers Assoc - If you love beer and haven't tried homebrewing... shame on you. Check out the valuable info on the AHA website, read John Palmer's How To Brew, then get yourself a kit. There will be no looking back.
South Hills Brewing Supply - Also now proud owners of Country Wines on Babcock Blvd. Very knowledgable and helpful staff, great store layout, and fresh ingredients. Highly recommended.
TRASH Homebrew Club - Sponsors of the annual TRASH homebrew competition and largest homebrew club in Pittsburgh.
TRUB Homebrew Club - Pittsburgh homebrew club. Meetings are open and new members are welcome.
TRUB Homebrew Club - Pittsburgh homebrew club. Meetings are open and new members are welcome.
Pittsburgh Brewmasters - Meets 2x per month at the Sharp Edge Brasserie and Sharp Edge Creekhouse. Cost is $15 for 6 samples.
Hash House Harriers - Ever considered mixing running and beer. Me neither, but this crazy group looks like alot of fun.
Pittsburgh Beer Ladies - Monthly beer gathering for gals that know there is more to beer than Blue Moon with an orange slice.